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Cytochrome P450 : Alphabetical drug list
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1A2 2C9 2C19 2D6 2E1 3A4
 
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Drug CYP interaction Clinical consequences
halofantrine 2D6 : INHIBITS ?
3A4, 3A5 : METABOLISM cardiotoxicity with e.g. ketoconazole, diltiazem, erythromycin, nifedipine, cyclosporine.
haloperidol (See also Antipsychotics) {main metabolism is via 3A4} CYP3A4 : hi activity ? less effective eg. with carbamazepine, rifampicin, phenytoin, phenobarbital [Clin Pharmacokinet 1999 Dec;37(6):435-56]
CYP3A4 : low activity delayed clearance
CYP1A2 metabolism : low activity ?
CYP2D6 : metabolism ?
2D6: inhibits e.g. inhibition of codeine effect
halothane 2E1 : metabolism ?
2A6 : oxidation (!) [Eur J Clin Pharmacol 2000 Feb-Mar;55(11-12):853-9] The metabolites result in rare but life-threatening cases of hepatitis.
anaerobically, halothane is metabolised by 2A6, 3A4 (reduction)! [Drug Metab Dispos 1996 Sep;24(9):976-83]. Lipid peroxidation may result, of uncertain clinical significance.
hexobarbital (See also Barbiturates) 2C19 : substrate ?
HIV protease inhibitors : see Protease inhibitors
HMG Co-A reductase inhibitors ('statins')
simvastatin & lovastatin;
also atorvastatin, cerivastatin, fluvastatin;
(pravastatin is NOT metabolised by 3A4)
3A4 : substrate 3A4 inhibitors raise levels = rhabdomyolysis eg with cyclosporine A, mibefradil, nefazodone and simvastatin or lovastatin
phenytoin lowers effect
hydrocodone 2D6 : metabolism (to hydromorphone) ? significant - See [J Pharmacol Exp Ther 1997 Apr;281(1):103-8] contrasted with [Clin Pharmacol Ther 1993 Nov;54(5):463-72]
3A4 : metabolism (?) ?
hydrocortisone 3A4 : substrate {with 3A5, 3A7 ?} ?
hydroxyzine (1st generation antihistamine) 2D6 : inhibits (Ki ~ 4-6 µM) ?


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1A2 2C9 2C19 2D6 2E1 3A4
 



Page author: jo@anaesthetist.com Last update: 2000-6-22